Prurigo nodularis - 痒疹
relevance score : -100.0%
ReferencesPrurigo nodularis 是一種慢性皮膚疾病，特徵為多個堅硬的腫塊與結節，常見於手臂與腿部外側。這些腫塊顏色介於肉色至粉紅色，且極度發癢。任何年齡層皆可能受影響，且常與其他引起慢性搔癢的皮膚疾病（如異位性皮膚炎）同時出現。治療選擇包括強效止癢藥、免疫調節劑以及針對神經系統的藥物。結節性癢疹的治療通常需要長期維持。
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
治療通常包括於受影響區域使用乳膏或注射類固醇。較嚴重或頑固的情況下，可能需要光療或免疫抑制藥物等治療。沙利度胺和來那度胺是嚴重病例的選擇，但它們可能會產生嚴重的副作用。與沙利度胺或來那度胺相比，較新的治療方法（opioid receptor antagonists、neurokinin-1 receptor antagonists）顯示出治療結節性癢疹的前景，且副作用較少。
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo 是一種皮膚疾病，其特徵包括長期搔癢（持續超過 6 週）、與抓傷相關的皮膚損傷，以及反覆抓傷的病史。此疾病涉及皮膚的神經發炎與纖維化。
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis 是一種慢性皮膚疾病，以發癢的結節為特徵。其確切病因尚不明朗，但免疫與神經因素似乎在搔癢—抓癢的惡性循環中起作用。目前，美國 FDA 尚未批准任何專門針對結節性癢疹的治療方法。
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ 治療 - 非處方藥
用肥皂清洗病變部位並無幫助，反而可能使情況惡化。非處方類固醇軟膏可能有助於緩解症狀，但通常需使用數週才見改善。持續服用抗組織胺亦能減輕搔癢。
#OTC steroid ointment
#OTC antihistamine
○ 治療
#Intralesional triamcinolone injection